Selected publications

Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. 2017.

Science 356:1026-1030.

Lucas T, Schäfer F, Müller P, Eming SA, Heckel A, Dimmeler S. Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice. 2017. Nat Commun 8:15162.

Ding X, Bloch W, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. 2016. Nat Commun 7:13226.

Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. 2016. Nat Commun 7:12972.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich A, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster  CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid cell-derived VEGF is required to maintain brain glucose uptake and to limit cognitive impairment in obesity. 2016. Cell 166:1338-1340.

Hos D, Bucher F, Regenfuss B, Dreisow M, Bock F, Heindl LM, Eming SA, Cursiefen C. Interleukin-10 indirectly regulates corneal lymphangiogenesis and resolution of inflammation via macrophages. 2016. Am J Pathol 186:159-71.

Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Migge T, Richardson R, Hammerschmidt M, Allen JE, Eming SA, IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. 2015. Immunity 43:803-16.

Knuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA. Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation. 2015. J Immunol 195:5296-308.

Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds. 2015. J Control Release 220:79-88.

Ding X, Lucas T, Marcuzzi GP, Pfister H, Eming SA, Distinct functions of epidermis- and myeloid cell-specific VEGF-A in human papillomavirus type 8-mediated tumorigenesis. 2015. Cancer Res 75(2):330-4.

Eming SA, Martin P, Tomic-Canic M, Wound Repair and Regeneration: Mechanisms, signaling, and translation. 2014 Sci Transl Med  6(265):265sr6.

Eming SA, Editorial special issue: Evolution of immune pathways in regeneration and repair: novel concepts and biomedical perspectives. 2014. Seminars in Immunology 26(4):275-6.

Marcuzzi GP, Awerkiew S, Hufbauer M, Schädlich L, Gissmann L, Eming SA, Pfister H. Tumor prevention in HPV8 transgenic mice by HPV8-E6 DNA vaccination. 2014.  Med Micribiol Immunol 203:155-163.

Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartman K, Roers A, Eming SA, Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis.  2014.  J Invest Dermatol  134:2005-2015.

Coutelle O, Hornig-Do H, Schiffmann L, Brunold M, Liwschitz M, Brinkmann K, Seeger JM, Piekarek M, Andree M, Hallek M, Krönke M, Eming SA, Wiesner R, Hacker U, Kashkar H, Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.  2014.  EMBO Mol Med 6:624-639.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.  2013.  J Clin Investv Jul 1. pii: 69210.

Traub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA. The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165.  2013.  Biomaterials 34(24):5958-68.

Hoffmann DC, Willenborg S, Koch M, Zwolanek D, Müller S, Becker AK, Metzger S, Ehrbar M, Kurschat P, Hellmich M, Hubbell JA, Eming SA. Proteolytic processing regulates placental growth factor activities.  2013.  J Biol Chem 21;288(25):17976-89.

Richardson R, Slanchev K, Kraus C, Knyphausen P, Eming SA, Hammerschmidt M. Adult zebrafish as a model system for cutaneous wound-healing research.  2013.  J Invest Dermatol 133(6):1655-65.

Willenborg S, Lucas T, Geert van Loo, Knipper J, Krieg T, Ingo Haase, Bent Brachvogel, Matthias Hammerschmidt, Nagy A, Ferrara N, Pasparakis M, Eming SA, CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.  2012.  Blood 120:613-625.

Wood W and Eming SA, Repair or Regenerate – How can we tip the balance?  2012.  EMBO Report 13(12):1040-1042.

Martino MM, Tortelli F, Mochizuki M, Traub S, Ben-David D, Khun GA, Müller R, Livne E, Eming SA, Hubbell JA, Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing.  2011.  Sci Transl Med 3:1-8

Hoffmann DC, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, Fugmann B, Davidson JM, Werner S. Krieg T, Eming SA. A pivotal role for alpha -1-antichymotrypsin in skin repair. 2011. J Biol Chem 19;286(33):28889-901.

Eming SA, Hubbell JA. Extracellular matrix in angiogenesis: dynamic structures with translational potential. 2011. Exp Dermatol 20(7):605-13

Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, Müller W, Roers A, Eming SA, Differential roles of macrophages in diverse phases of skin repair.  2010.  J Immunol 184(7):3964-77.

Eming SA, Hammerschmidt M, Krieg T, Roers A, Interrelation of immunity and tissue repair or regeneration.  2009.  Seminars in Cell and Developmental Biology 20(5):517-27.

Buchstein N, Hoffmann N, Smola H, Lang S, Paulsson M, Niemann  C, Krieg T, Eming  SA.  Alternative proteolytic processing of hepatocyte growth factor during wound repair.  2009.  Am J Pathol 174(6):2116-28.

Eming SA, Smola H, Malchau G, Krieg T, Smola-Hess S, Polyacrylatesuperabsorber inhibits MMP activity in chronic wounds. 2008.  Biomaterials 29(19):2932-40

Eming SA, Werner, S., Bugnon, P., Utermöhlen, O., Wickenhauser, C., Davidson, J., Krieg, T., Roers, A. Accelerated wound closure in mice deficient for interleukin-10.  2007.  Am J Pathol 170:188-202.

Eming SA, Brachvogel B, Odorisio T, Koch M, Regulation of angiogenesis:  wound healing as a model.  2007.  Progress in Histochemistry and Cytohistochemistry 42(3):115-70.

Eming SA, Krieg T, Davidson JM,  Inflammation in wound repair: molecular and cellular mechanisms.  2007.  J Invest Dermatol, Invited Perspective Article 127:514-525.

Eming SA, Krieg T, Davidson JM,  Gene therapy and wound healing.  2007.  Clinics in Dermatology 25:79-92.

Eming SA, Smola-Hess S, Hirche D, Kurschat P, Krieg T, Smola H, A novel property of Povidon-iodine: inhibition of excessive protease levels in chronic non-healing wounds. 2006.  J Invest Dermatol 126, 2731-2733.

Athanasopoulos A, Economopoulou, Orlova V , Song K, Sobke A, Schneider D, Weber H, Augustin H, Eming SA, Schubert U, Linn T, Nawroth P, Hussain M, Hammes H, Herrmann M, Preissner KT, Chavakis T, The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. 2006.  Blood 107, 2720-2727.

Roth D, Piekarek M, Christ H, Paulsson M, Bloch W, Krieg T, Davidson J, Eming SA, Plasmin modulates VEGF-A mediated angiogenesis during wound repair.  2006.  Am J Pathol. 168:670-684.

Eming SA, Krieg T, Molecular mechanisms of VEGF-A action during tissue repair.  2006.  J Invest Dermatol, 126 Suppl:79-86.

Eming SA, Lauer G, Cole M, Jurk S, Christ H, Hornig C, Krieg T, Weich H,  Increased levels of the soluble variant of the VEGF receptor VEGFR-1 (sFlt-1) are associated with poor prognosis in wound healing.  2004.  J Invest Dermatol 123:799-802.

Eming SA, Krieg T, Davidson JM, Gene transfer in tissue repair:  current status, challenges, future directions.  2004.  Expert Opinion on Biological Therapy 4:1373-1386.

Lauer G, Sollberg S, Cole M, Krieg T, Eming SA, Generation of a novel proteolytic resistant VEGF165 variant by a site directed mutation at the plasmin sensitive cleavage site.  2002. FEBS Letter 531:309-313.

Eming SA, Smola H, Krieg T, The treatment of chronic wounds:  current concepts and future aspects.  2002.  Cells Tissues Organs 172:105-117.

Eming SA, Peters T, Hartmann K, Scharffetter-Kochanek K, Mahrle G,  Lichenoid chronic graft-versus-host like acrodermatitis induced by hydroxyurea (Litalir®).  2001.  J Am Acad Dermatol  45:321-323.

Smola H, Eming SA, Hess S, Werner S, Krieg T, Wundheilung und Wundheilungsstörungen - Moderne Konzepte zur pathophysiologie und Therapie.  2001.  Deutsches Ärzteblatt 98:2400-2406.

Davidson JM, Krieg T, Eming SA, Particle mediated gene transfer of wounds.  2001.  Wound Repair and Regeneration 8:452-459.

Eming SA, Davidson JM, Krieg T,  Gene transfer strategies in tissue repair.  2001.  In: The skin and gene therapy.  Eds.:  U.R. Hengge, B. Volc-Platzer, pp.117-137, Springer-Verlag, Berlin, Heidelberg.

Lauer G, Sollberg S, Cole M, Flamme I, Mann K, Krieg T, Eming SA, Expression and Proteolysis of VEGF is increased in chronic wounds.  2000.  J Invest Dermatol 115:12-18.

Eming SA, Krieg T,  Die Biologie der Wundheilung.  2000.  In:  Fortschritte der operativen und onkologischen Dermatologie Band 16 Krankheiten der Hautanhangsgebilde, Wund- und Narbenmanagement.  Eds.:  Koller, Hintner; pp.137-141, Blackwell Wissenschafts-Verlag, Berlin.

Eming SA, Whitsitt JS, He L, Krieg T, Morgan JR, Davidson JM, Particle-mediated gene transfer of PDGF promotes tissue repair.  1999.  J Invest Dermatol  112:297-302.

Eming SA, Yarmush ML, Morgan JR, Regulation of the spatial organization of mesenchymal connective tissue.  1999.  Am J Pathol 154:281-289.

Eming SA, Morgan JR, Davidson JM, Krieg T,  Neue experimentelle Strategien zur Therapie von Wundheilungsstörungen.  1999.  In:  Dermatologie an der Schwelle zum neuen Jahrtausend.  Eds.:  A. Plettenberg, W.N. Meigel, I. Moll, pp.575-577, Springer-Verlag, Berlin, Heidelberg.

Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR,Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft.  1998.  Human Gene Therapy  9:529-539.

Eming SA, Morgan JR, Methods for the use of genetically-modified kratinocytes in gene therapy.  1997.  In: Methods in Molecular Biology, Gene therapy protocols , Ed.: P. Robbins, pp. 265-281, Humana Press, Totowa, New Jersey.

Medalie DA, Eming SA, Collins ME, Tompkins RG, Yarmush ML, Morgan JR, Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane and rete ridge formation of transplanted composite skin grafts.  1997.  Transplantation 64:454-465.

Eming SA, Morgan JR, Berger A, Gene Therapy for Tissue Repair:  Approaches and Prospects.  1997.  Brit J Plast Surg 50:491-500.

Eming SA, Morgan JR, Methods for the use of genetically-modified kratinocytes in gene therapy.  1997.  In: Methods in Molecular Biology, Gene therapy protocols , Ed.: P. Robbins, pp. 265-281, Humana Press, Totowa, New Jersey.

Eming SA, Yarmush ML, Morgan  JR,  Enhanced function of cultured epithelium by genetic modification:  cell-based synthesis and delivery of growth factors.  1996.  Biotechnology and Bioengineering  52:15-23.

Medalie DA, Eming SA, Tompkins RG, Yarmush ML, Krueger GG, Morgan JR, Evaluation of human skin reconstituted from composite grafts of cultured keratinocyts and human acellular dermis transplanted to athymic mice.  1996. J Invest Dermatol  107:121-127.

Eming SA, Snow RG, Yarmush ML, Morgan JR, Targeted expression of IGF-1 to human keratinocytes:  Modification of the autocrine control of keratinocyte proliferation.  1996. J Invest Dermatol  107:113-120.

Eming SA, Lee J, Snow RG, Tompkins RG, Yarmush ML, Morgan JR, Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice.  1995.  J Invest Dermatol 105:756-63.

Duchosal MA, Eming SA, Fischer P, Leturcq D, McConahey PJ, Caothien RH, Thornton GB, Dixon FJ, Burton DR, Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments.  1992.  Nature 355:258-62.